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Unfold Therapeutics

We are developing a laser system designed to safely treat conjunctivochalasis—a prevalent condition among aging individuals, characterized by a loose conjunctiva causing chronic eye redness, irritation, and blurry vision. Our aim is to address the needs of an estimated 30 million Americans suffering from moderate to severe conjunctivochalasis. Our proposed Laser Thermal Conjunctivoplasty (LTC) device facilitates a safe, quick, and minimally invasive procedure that can be conveniently carried out in an ophthalmologist's office. By employing a novel handpiece utilizing a near-infrared laser, the LTC device accurately targets and heats the conjunctiva, causing shrinkage with minimized collateral damage and scarring.

Founders

David Huang, MD PhD

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Dr. David Huang is the Chief Executive officer of Unfold Therapeutics. He is a Professor of Ophthalmology and of Biomedical Engineering at the Oregon Health & Science University (OHSU). He is also the Associate Director and Research Head at the Casey Eye Institute. With degrees from MIT and the joint Harvard-MIT Health Sciences Program, he's a co-inventor of Optical Coherence Tomography (OCT), a pivotal ophthalmic imaging technology. His notable article on OCT has garnered over 17,000 citations. Holding 42 patents and having published over 300 peer-reviewed articles, Dr. Huang's has received prestigious awards. Among these are the Lasker Award, the Antonio Champalimaud Vision Award, the Russ Prize, and the Jonas Friedenwald Award. Dr. Huang also leads the Center for Ophthalmic Optics and Lasers and is the inventor and co-founder of GoCheck which has screened over 5 million children for amblyopia risk factors.

Stephen Pflugfelder, MD

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Dr. Stephen Pflugfelder is the Chief Medical Officer of Unfold Therapeutics. He holds the distinguished James and Margaret Elkins Chair at Baylor College of Medicine, where he also spearheads the Ocular Surface Center in the Department of Ophthalmology. A past president of the International Ocular Surface Society, Dr. Pflugfelder currently serves on editorial board of the journal The Ocular Surface. With a remarkable 30-year dedication to unraveling the complexities of ocular surface diseases, particularly those originating from dry eye conditions, his clinical practice specializes in the treatment of cornea, ocular surface, and tear disorders. Dr. Pflugfelder's academic contributions are showcased through his co-editorship of the textbook Dry Eye and Ocular Surface Disorders and the publication of over 300 peer-reviewed articles.

Scott Prahl, PhD

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Scott Prahl is the Chief Technology Officer at Unfold Therapeutics. He is a Professor of Electrical Engineering and Renewable Energy at Oregon Institute of Technology. Since his doctoral work in Biomedical Engineering from the University of Texas at Austin, Dr. Prahl has worked to advance biomedical optics through modeling light transport through tissue, creating methods to measure tissue's intrinsic scattering and absorption properties, and developing therapies utilizing light for healing, such as photoacoustic drug delivery and laser thrombolysis. He is currently teaching and directing the optical engineering program at Oregon Tech. He has contributed over 75 refereed papers, several patents, maintains the widely used OMLC biomedical optics website, and has a variety of Github repositories.